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Submitted By dsanderson
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The French ambassador in Portugal, Jean Nicot de Villemain, sent tobacco and seeds to Paris from Brazil in 1560, saying that tobacco had medicinal uses. From his name came the Latin name for the tobacco plant - Nicotianana tabacum.
Nicot sent snuff - powdered tobacco that is sniffed through the nostril to, the Queen of France at the time. He said it would treat her migraines. Nicot, who suffered from headaches, said the snuff helped relieve symptoms. The Queen tried it and said it was effective. She said that tobacco should be called the Herba Regina (the herb of the queen).
In 1828, Posselt, a doctor, and Reinmann, a chemist, both from Germany, first isolated nicotine from the tobacco plant. They said it was a poison. a Belgian chemist and physicist, described nicotine's empirical formula in 1843, and Adolf Pinner and Richard Wolffenstein, both chemists from Germany, described its structure in 1893
In 1904, nicotine was first synthesized .
Pharmacokinetics refers to what the body does to a substance, while pharmacodynamics refers to what a substance does to the body.
After inhaling tobacco smoke, nicotine rapidly enters the bloodstream, crosses the blood-brain barrier and is inside the brain within eight to twenty seconds. Within approximately two hours after entering the body, half of the nicotine has gone (elimination half-life of about two hours).
How much nicotine may enter a smoker's body depends on:
• what type of tobacco is being used
• whether or not the smoker inhales the smoke
• whether a filter is used, and what type of filter it is
Tobacco products that are chewed, placed inside the mouth, or snorted tend to release considerably larger amounts of nicotine into the body than smoking. Nicotine is broken down (metabolized) in the liver, mostly by cytochrome P450 enzymes. Nicotine is both a sedative and a stimulant. When our bodies are exposed…...

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